pathophysiology

In this article the authors used state-of-the-art multiplexed immunostaining of human brains and demonstrated that expression of the SARS-CoV-2 receptor ACE2 is restricted to a subset of neurovascular pericytes.

This overview attempts to give a thorough insight into SARS-CoV-2 neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.

In this article the authors have developed a postmortem bedside surgical procedure to harvest endoscopically samples of respiratory and olfactory mucosae and whole olfactory bulbs.

In this article the authors report an analysis of postmortem COVID-19 cases that provides proof of viremia and presence of replication-competent SARS-CoV-2 in extrapulmonary organs of immunocompromised patients, including heart, kidney, liver, and spleen.

In this article the authors describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology.

This Review provides the structural and cellular foundations for understanding the multistep SARS-CoV-2 entry process.

In this review, the authors summarize possible mechanisms by which infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, may cause AD in elderly COVID-19 patients and describe preventive measures to mitigate risk.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited.

In this article the authors present a systematic review, carried out according to the Preferred Reporting Items for Systematic Review standards, of the neuropathological features of COVID-19.

In this article the authors performed a systematic literature review on neuropathological studies in COVID-19, including 438 patients from 45 articles published by April 22, 2021.

  The XXIII World Congress of the International Association of Parkinson’s Disease and Related Disorders (IAPRD) was held from August 19th to 22th, 2018, in Lyon, France, at the Lyon Convention Centre, a beautiful location designed by the famous Italian… Continue Reading

History Machado-Joseph disease (MJD) is an autosomal dominant (AD) spinocerebellar ataxia (SCA) initially described in descendants of immigrants from the Portuguese islands of the Azores. It was in 1972 that Kenneth K. Nakano and colleagues described the Machado family, with an AD, late onset, cerebellar ataxia with peripheral neuropathy. All family members were descendants from Guilherme Machado, who had migrated from São Miguel (Azores) to Massachusetts in the late nineteenth or early twentieth centuries.