Title of the project: “Delineating the molecular mechanisms of mitochondrial DNA disease: clinical and pathological studies”
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by Delia Lenzi Researchers working with gene-editing techniques (CRISPR) have managed to ensure that an engineered mosquito would pass on its new Plasmodium falciparum resistance genes to nearly all of its offspring— and note, not just half, as would normally… Continue Reading
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by Delia Lenzi Using an increasingly popular gene-editing toolkit called CRISPR, Gantz and Bier were able to overcome the classic rules of Mendelian genetics. This is an impressive example of gene drive: biasing inheritance to spread a gene rapidly through… Continue Reading
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…but too innovative to be stopped. by Delia Lenzi Starting with the skin cells of mice in vitro, the japanese molecular biologist Katsuhiko Hayashi created primordial germ cells (PGCs), which can develop into both sperm and eggs. To prove that… Continue Reading
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Grand Rounds
Case Report: LGMD-2B: Clinical phenotype and diagnosis 50 years after the first symptoms
presented by João Martins and Luís Santos We report the case of a 75-year-old lady who at the age of 25 initiated slowly progressive proximal paresis of lower limbs, and became dependent of a wheelchair when 30 years old. At… Continue Reading -
Top 10 Articles
Top Article: Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Abstract
We report the results of a meta-analysis of genome-wide association scans for multiple sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects. Replication in an independent set of 2,215 subjects with MS and 2,116 control… Continue Reading