Research

Disability through COVID-19 pandemic: Neurorehabilitation cannot wait

Here are the news from the Coma and Disorders of Consciousness panel for May and June, including feedback from the Virtual EAN Congress, new diagnostic and prognostic tools, personalized pain assessment methods and epidemiological data on dysphagia.

For August 2020, we have selected Turner R.S. et al. “Nilotinib Effects on Safety, Tolerability,and Biomarkers in Alzheimer’s Disease” Annals of Neurology 2020;88:183–194. doi: 10.1002/ana.25775. Epub 2020 May 28.

For August 2020, we have selected Rogers J.P. et al. “Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic” Lancet Psychiatry 2020; 7:611-627.

This Guideline addresses a number of medical issues which neurologists and other medical doctors who are involved in the medical management of patients with dementia are confronted with on a regular basis.

In this study recently published in Brain, the authors collected detailed clinical and paraclinical data from patients with suspected COVID-19-related neurological disorders in whom the diagnosis of COVID-19 was confirmed through RNA PCR, or where the diagnosis was probable/possible according to World Health Organisation criteria.

In this research letter recently published in JAMA, the authors assessed persistent symptoms in patients who had been discharged from hospital after recovery from COVID-19.

Anosmia, stroke, paralysis, cranial nerve deficits, encephalopathy, delirium, meningitis, and seizures are some of the neurological complications in patients with COVID-19.

In this study, recently published in Brain, the authors present cerebrovascular disease case incidence in hospitalised patients with SARS-CoV-2 infection.

In this paper, the authors retrospectively reviewed all COVID-19–positive patients admitted to the neuroscience intensive care unit for monitoring of malignant cerebral oedema

In this paper recently published in Acta Neuropathologica, the authors report neuropathology of two COVID-19 patients.

In this paper, the authors pooled all consecutive patients hospitalised with laboratory-confirmed COVID-19 and acute ischaemic stroke across 28 sites from 16 countries.

In this paper, the authors report a case of a previously healthy 58-year-old man who acutely developed hyposmia, generalised myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities following severe SARS-CoV-2 infection.

In this review recently published in JAMA, the authors summarise the current evidence regarding the pathophysiology, transmission, diagnosis, and management of COVID-19.

In this multicentre retrospective observational study, the authors analysed the impact of the COVID-19 pandemic on hospital stroke admissions and in-hospital mortality in tertiary referral hospitals in north-west Spain.