Research

Interleukin-1 and interleukin-6 inhibition compared with standard management in patients with COVID-19 and hyperinflammation: a cohort study

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine — Preliminary Report

Patients using angiotensin-II-stimulating antihypertensives have 45% lower risk to develop demenia compared to those that use angiotensin-II-inhibiting antihypertensives.

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders

Blood phosphorylated tau 181 as a biomarker for Alzheimer’s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

Longitudinal neuroimaging biomarkers differacross Alzheimer’s disease phenotypes

The section of Scales and Scores provides a database of scales and scores used in neurology. It provides researchers in the field with access to the most commonly available and validated scales and scores.

Auditory localization should be considered as a sign of consciousness, as unresponsive patients who demonstrate this behaviour show increased brain activity and better outcomes, comparable to patients in minimally conscious state.

The process of end-of-life decision-making for patients with disorders of consciousness should include caregivers in bedside assessments and integrate advanced diagnostic brain imaging techniques when available.

An international study showed that younger age, shorter time since injury, higher level of responsiveness and EEG reactivity to eye opening are all factors that can predict 6-month improvement among severely brain-injured patients.

Habituation of auditory startle reflex should be considered as a sign of the minimally conscious state, as unresponsive patients who demonstrate this behaviour show increased brain activity and better outcomes compared to patients with inextinguishable startle reflexes.

A Dutch nationwide prospective cohort study has been launched to monitor the outcomes of patients included in the Early Intensive Rehabilitation program, with a follow-up period of two years.

Neurology Update: Coma and Chronic Disorders of Consciousness