Multiple system atrophy (MSA) is a rare, fatal, neurodegenerative disease of the adulthood presenting with progressive autonomic failure, parkinsonian, cerebellar and pyramidal features in various combinations.
Distinguishing the Parkinson-variant of MSA (MSA-P) from Parkinson’s disease (PD) is often difficult due to overlapping clinical features. This is a major drawback for counselling of patients and timely enrollment into disease-modifying clinical trials.
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