Cognitive functioning and multimodal neuroimaging in narcolepsy type 1
In the context of frequent subjective memory complaints of patients with narcolepsy type 1 in clinical practice a recent study showed significant volume loss of the anterior hippocampus which was not related to objective cognitive performance. These structural changes may affect functional connections between the anterior hippocampus, medial prefrontal cortex and the amygdala and render patients more susceptible to cataplexy. Diffusion tensor imaging revealed reduced structural integrity of widespread connections passing through the ventral diencephalon and hypothalamus.
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