DNA methylation editing tools: a promising approach in Fragile X syndrome and other neurodegenerative diseases.
Fragile X Syndrome (FXS), the most common genetic form of intellectual disability in males is caused by a CGG trinucleotide repeat (>200) expansion mutation at the 5’-UTR of FMR1, accompanied by DNA hypermethylation that is thought to result in heterochromatin formation at the FMR1 promoter and subsequent silencing of FMR1 expression in FXS. Recently, DNA methylation editing tools have been developed to reverse the…
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