Neurology Update from Scientific Panel Multiple Sclerosis
In a recent study by Filippi et al. (https://pubmed.ncbi.nlm.nih.gov/34716250/), the Authors showed that the 2017 McDonald criteria have higher sensitivity, lower specificity, and overall similar accuracy compared with the 2010 McDonald criteria in predicting clinically definite multiple sclerosis development independently from the type of clinical onset. These criteria simplify the clinical use of MRI criteria without reducing accuracy and allow an earlier diagnosis of MS. The Authors also suggested that three periventricular lesions should be considered in future revisions of the McDonald criteria to improve specificity and accuracy in older patients with clinically isolated syndrome.
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