COVID Breaking news: CNS injury biomarkers elevated in COVID patients
Kanberg et al., 2020: Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19.
In this paper, the authors investigated the level of neuronal injury and glial activation in patients affected by COVID-19 by measuring the plasma level of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp). GFAp is a marker of axonal injury and NfL of axonal lesion; both biomarkers measured in plasma and CSF can reliably detect CNS injury and correlate with prognosis in a variety of neuropathological conditions.
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