In this article, just published in the New England Journal of Medicine, Beigel et al. conducted a double-blind, randomised, placebo-controlled trial of intravenous remdesivir in adults hospitalised with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days. The primary outcome was the time to recovery, defined by either discharge from hospital or hospitalisation for infection-control purposes only. A total of 1063 patients underwent randomisation. The data and safety monitoring board recommended early unblinding of the results on the basis of findings from an interim analysis that showed shortened time to recovery in the remdesivir group. Preliminary results from the 1059 patients (538 assigned to remdesivir and 521 to placebo) with data available after randomisation indicated that those who received remdesivir had a median recovery time of 11 days (95% confidence interval [CI], 9 to 12), as compared with 15 days (95% CI, 13 to 19) in those who received placebo (rate ratio for recovery, 1.32; 95% CI, 1.12 to 1.55; P<0.001). The Kaplan-Meier estimates of mortality by 14 days were 7.1% with remdesivir and 11.9% with placebo (hazard ratio for death, 0.70; 95% CI, 0.47 to 1.04). Serious adverse events were reported for 114 of the 541 patients in the remdesivir group who underwent randomisation (21.1%) and 141 of the 522 patients in the placebo group (27.0%). The authors concluded that remdesivir was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19 and evidence of lower respiratory tract infection.
https://www.nejm.org/doi/full/10.1056/NEJMoa2007764
by Marialuisa Zedde and Francesco Cavallieri
