Vagal nerve stimulation may improve post-stroke motor recovery
The Vagus Nerve Stimulation (VNS) may promote reorganization of motor networks via engaging a variety of molecular and neuronal mechanisms through ascending neuromodulatory systems. A recently published review from Frontiers in Neuroscience (N.D. Engineer et al. Targeted Vagus nerve stimulation for rehabilitation after stroke, Front Neurosci. 2019, 29;13:280) has laid out how recent experimental and clinical studies are providing increasing evidence for a beneficial effect of vagus nerve stimulation for the motor recovery after stroke of both, ischemic and hemorrhagic origin. Two multi-site, randomized controlled pilot trials have suggested that when paired with neurorehabilitation, VNS stimulation may generate temporally precise neuromodulatory feedback within the synaptic eligibility trace and may hence, drive synaptic plasticity.
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