EXTEND study: More evidence on thrombolysis beyond traditional time windows
After the WAKE-UP study showed that intravenous thrombolysis improved outcomes in ischemic stroke patients with unknown symptom onset based on advanced MRI imaging, the EXTEND study now provides new insights on thrombolysis beyond the traditional time window of 4.5 hours.
In this multicentre, randomized, placebo-controlled trial, patients with ischemic stroke were included if their symptom onset was between 4.5 and 9 hours or on awakening (if the midpoint of sleep was within 9 hours) and if …
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