by Delia Lenzi
A study in mice published in Nature Neuroscience this year provides important insights on schizophrenia pathogenesis by linking the three previous and, until now, apparently unrelated hypotheses: the “spine pruning theory”, the “hyperactive neurons theory” and the “dopamine hypothesis”. The common path seems to be the disruption of a critical regulator of the dendritic spine cytoskeleton, the actin-related protein 2/3 complex (Arp2/3).
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